A recent study measured GABAergic responses in vivo with iGABASnFR, a genetically engineered GABA sensor, in 6 months old 3xTg-AD mice, and found reduced GABAergic responses in the hilus, as compared to Vgat-WT mice [55], suggesting impaired GABA transmission during early AD. Here, SLC32A1 is linked to Alzheimer disease.