The heat map and the box plot showed that compared with the mice in the ApoE−/− + NF group, 10 types of CE, 20 types of TAG, 30 types of PL, 2 types of FFA, 2 types of sphingomyelin (SM), 1 types of acylcarnitine (Acy), and 1 type of ceramide (Cer) were significantly transformed in the plasma of the ApoE−/− + HF group (Fig. 1I-M). The gene discussed is APOE; the disease is hydrops fetalis.