As shown in Fig. 8B, MAPK signaling pathway (NES = 1.42, P = 0.018), neuroactive ligand-receptor interaction (NES = 1.25, P = 0.045), acute myeloid leukemia (NES = 1.51, P = 0.029), toll-like receptor signaling pathway (NES = 1.51, P = 0.025), and NOD-like receptor signaling pathway (NES = 1.66, P = 0.008) were enriched in the IL1R1 high-expressed phenotype. Here, IL1R1 is linked to acute myeloid leukemia.