As shown in Fig. 3, these 121 DEIRGs were mainly enriched in primary immunodeficiency, regulation of cell activation, response to a bacterium, cytokine-cytokine receptor interaction, chemotaxis, cell chemotaxis, regulation of chemotaxis, and JAK-STAT signaling pathway, etc. The findings implied that DEIRGs were significantly enriched in immune-related pathways, which have been associated with AD and MDD. The gene discussed is SOAT1; the disease is major depressive disorder.