As shown in Fig. 8A, primary immunodeficiency (NES = -1.5, P = 0.049) and intestinal immune network for IGA production (NES = -1.51, P = 0.043) were enriched in the CHGB high-expressed phenotype, while chemokine signaling pathway (NES = 1.34, P = 0.035) and Alzheimer’s disease (NES = 1.57, P = 0.017) were enriched in the CHGB low-expressed phenotype. The gene discussed is CHGB; the disease is early-onset autosomal dominant Alzheimer disease.