As shown in Fig. 7C, primary immunodeficiency (NES = -1.31, P = 0.15), neuroactive ligand-receptor interaction (NES = -1.38, p = 0.06), and drug metabolism other enzymes (NES = -1.53, P = 0.026) were enriched in the NRG1 low-expressed phenotype. The gene discussed is NRG1; the disease is inborn error of immunity.