IL1R1 and major depressive disorder: Functional enrichment analysis revealed that MDD and AD shared some of the common pathways: primary immunodeficiency, cytokine-cytokine receptor interaction, and JAK-STAT signaling pathway, etc. Furthermore, correlation analysis revealed that both IL1R1 and NRG1 expression are significantly associated with neutrophils, endothelial cells, and myeloid dendritic cell infiltrations in AD and MDD.