For the rarity of Xp11.2 tRCC, case reports were also included and our search items were likely to be inadequate for all cases included, in addition, clinicopathological data form RCC were applied to confirm the role of Rad54l2 in diagnostic and prognosis value, which might seem to be unreasonable. This evidence concerns the gene RAD54L2 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.