TP53 and cancer: Ferroptosis is associated with the anti-tumor function of several tumor suppressors, such as BRCA1-associated protein 1 (BAP1), p53, et al. SLC7A11 is highly expressed in human cancers, and its over-expression suppresses ROS-induced ferroptosis and eliminates p53(3KR)-mediated tumor growth inhibition in xenograft models [46].