PLA2G4A and cancer: PLA2G4A, an enzymatic member of the A2 family IV family of cytosolic phospholipases, metabolizes arachidonic acid (AA) to eicosanoid, and PLA2G4A is regulated by transcription factor 6α (ATF6α), which can accelerate arachidonic acid metabolism by upregulating PLA2G4A to avoid ferroptosis in cancer cells [65].