Identification of significant signaling pathways using the KEGG database shows that candidate hub genes were mainly involved in Glioma, Melanoma, Prostate cancer, Non − small cell lung cancer, Renal cell carcinoma, GnRH secretion, Aldosterone − regulated sodium reabsorption, and Pancreatic cancer (Fig. 6). Here, GNRH1 is linked to hereditary clear cell renal cell carcinoma.