Interestingly, three Vps1 mutants, I277G, G397R, and I442G, corresponding to DNM1 V235G, DNM2 G358R, and DNM2 V375G mutations found in microcytic anemia, Charcot-Marie-Tooth, and centronuclear myopathy, respectively, showed a defect in autophagic flux (Fig. 6B). This evidence concerns the gene DNM2 and autosomal dominant centronuclear myopathy.