DNM1L and lethal congenital contracture syndrome: Due to the high conservation between human dynamins and yeast Vps1, with approximately 32% amino acid sequence identity, we identified all the corresponding mutations reported to cause the Charcot-Marie-Tooth disorder, epileptic encephalopathy, microcytic anemia, centronuclear myopathy, hereditary spastic paraplegia, and lethal congenital contracture syndrome, but also exercise-induced collapse in Labradors and epilepsy in the fitful mouse model in Vps1 (Fig. S6 and Table 2).