Still, 12 genes were common to five or more cell states, as exemplified by matrix Gla protein (Mgp), stem cell antigen-1 (Sca1; also called Ly6A) and legumain (Lgmn), syndecan 4 (Sdc4), and insulin-like growth factor binding protein 4 (Igfbp4), and could thus represent global markers of atherosclerosis. The gene discussed is LY6S; the disease is atherosclerosis.