Omics studies have already revealed several defects in the immune system of IgAN patients; however, we still do not fully understand the immunopathology behind the disease, for example, why certain individuals have increased Gd-IgA1 levels and do not develop kidney disease, where the production of Gd-IgA1 occurs, and why immunocomplexes deposit in the kidney and how they cause damage. This evidence concerns the gene IGHA1 and kidney disorder.