Consistently, circulating adiponectin is lower in individuals with type 2 diabetes compared to healthy individuals, and well as those with risk factors such as obesity (Bahia et al., 2006; Choi et al., 2007; Eglit et al., 2013; Hotta et al., 2000; Xydakis et al., 2004). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.