MTAP and familial pancreatic carcinoma: More recently, we found that a key enzyme related to the salvage of methionine and adenine, methylthioadenosine phosphorylase (MTAP) is deficient in 20%–30% of pancreatic cancer and metabolic reprogramming mediated by its deletion enhances glycolysis and de novo synthesis of purines in pancreatic cancer cells, resulting in a poor prognosis for pancreatic cancer patients.55