NRG4 and obesity due to melanocortin 4 receptor deficiency: As impaired Oxt release from the PVN is involved in DIO pathogenesis, its blockage via gentic or pharmacologic interventions promoted body weight loss, while treatment of Oxt can effectively correct hyper‐appetite and obesity.[22] We explored whether Nrg4‐ErbB4 signaling regulates Oxt release.