demonstrated that the expression of Nrg4 is a novel marker of beige adipocytes in human adipose tissue.[27] Moreover, recent studies have demonstrated that Nrg4 stimulates browning of WAT,[28] exacerbates BAT activity,[29] enhances blood vessels of adipose tissue, increases neurite outgrowth through neuronal interactions in adipose tissues,[26] and inhibits the development of hepatocellular carcinoma.[30] Interestingly, the Nrg4 receptor ErbB4 is abundantly expressed in the hypothalamus.[19] Zhang et al. Here, NRG4 is linked to hepatocellular carcinoma.