Oxt, a hypothalamic neuropeptide that induces parturition and lactation in females, is synthesized and released by neurons that are predominantly localized in the PVN and SON of the hypothalamus.[35] Recent research has focused on the role of PVN Oxt in suppressing food intake and promoting energy intake.[18] Oxt[23a] or OTR deletion[23b] promotes the development of hyper‐appetite and obesity in mice. Here, OXTR is linked to obesity due to melanocortin 4 receptor deficiency.