MAPT and myeloid sarcoma: Then, we investigated the causal role of tau accumulation in MS lesions by stereotaxically infusing pAAV-CAG-hTau-eGFP (serotype: AAV2/8, viral titers: 1.27 × 1013 vg/ml, 0.8 μl) into the MS of C57BL/6 mice (MS-hTau mice).