Distinct differences were observed between children presenting with CM and the healthy children with the analysis showing the following cytokines IFN-γ, IL-2, IL-6, IL-7, IL-8, IL-10, IL-13, and TNF and being significantly higher in CM patients than in controls (P < 0.05) (Fig. 1A, C). Here, IL2 is linked to cutaneous mastocytosis.