The NFE2L2 gene is now mostly studied in the cancer field; in esophageal squamous cell carcinoma NFE2L2 may confer oncogenic activity [39]; in cervical squamous carcinoma it is involved in immune prognosis, mainly acting in the tumor microenvironment [40]; autophagy and the NFE2L2 pathway activate ubiquitin ligases in prostate cancer [41]. This evidence concerns the gene NFE2L2 and Familial prostate cancer.