Considering the entire screened subpopulation, patients carrying PGVs were younger (chi-square corrected p = 0.01, five tests) and had tumors with higher Ki67 scores (p < 0.001), higher NHG status (grade 3, p < 0.001), and higher ROR scores (p < 0.001) than patients without PGVs but showed no difference in tumor size (p = 0.6) (Additional file 2: Table S8). Here, MKI67 is linked to neoplasm.