Taken collectively with our data showing that the level of LXRβ protein in T47D:dKO:CLDN4:LXRβS432A cells was similar to that in T47D:dKO:CLDN4:LXRβ cells (Fig. 5B), these results revealed that LXRβS432A is critical for the CLDN4-provoked breast cancer metabolism and advancement. The gene discussed is NR1H2; the disease is breast cancer.