Taken together with the findings showing that LXRα controls the growth of skin and oral squamous cell carcinoma by altering the cholesterol homeostasis [49, 50], our results suggest that the CLDN4 signaling promotes cell proliferation in breast cancer cells, possibly by LXRβ-mediated control of genes involved in cancer metabolism. The gene discussed is NR1H2; the disease is oral cavity squamous cell carcinoma.