EIF2S1 and thyroid cancer: S100A11 participated in protein polyufmylation, regulation of translational initiation by EIF2 alpha phosphorylation, development of secondary female sexual characteristics, regulation of mitochondrial electron transport NADH to ubiquinone, development of secondary sexual characteristics, and other GO functions and KEGG pathways such as epithelial cell signaling in Helicobacter pylori infection, ubiquitin-mediated proteolysis, pancreatic cancer, thyroid cancer, non-small cell lung cancer (Fig. 7C, D).