Consistent with this expression, TTBK1/2 have described pathological roles specific to the central nervous system and brain, such as in Alzheimer’s disease (AD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and a spinocerebellar ataxia type 11 (SCA11)7. The gene discussed is TTBK1; the disease is spinocerebellar ataxia type 11.