Conversely, in TCGA, prognostic accuracy was highest for the clinical nomogram (C-Index 0.644, Supplementary Table 7), although no treatment information was available, and prognosis in this cohort was worse than expected for HR + /HER2- breast cancer receiving modern treatment regimens (Supplementary Fig. 2)15,16. This evidence concerns the gene ERBB2 and breast carcinoma.