Second, the genes that contribute to the invasion capacity of GBM cells in the EGFR/PI3K/AKT pathway, including TNC, FN1, and COL1A1, were also down-regulated after CEBPD knockdown in both normoxic and hypoxic conditions (Fig. 6A, Supplementary Figure S7). This evidence concerns the gene COL1A1 and glioblastoma.