Interestingly, most of these proteins are ECM molecules and contribute to the invasiveness of glioma cells, including FN1 [46], TNC [47], LAMC1 [48], COL1A1 [19, 48], EGFR [49], CDK6 [50], and COL6A2 [51]. This evidence concerns the gene COL6A2 and central nervous system cancer.