ATF4 and non-small cell lung carcinoma: Taking cues from a previous study reporting SESN2 upregulation in non-small cell lung cancer cells, we investigated the role of the transcription factors ATF4 (activating transcription factor 4) and NRF2 (nuclear factor erythroid 2-related factor 2) [43] in activating SESN2 expression under glucose deprivation in HepG2 cells.