Moreover, different cancer-overexpressed non-coding RNAs also promote HK2 mRNA stability, with circCDKN2B-AS1 complexing with IGF2BP3 and HK2 mRNA to sustain aerobic glycolysis [33], while the related IGF2BP2 protein also increases HK2 mRNA stability through forming a complex with the lncRNA CASC9 [34]. This evidence concerns the gene HK2 and cancer.