MPI and acute myeloid leukemia: Conversely, given that glucose, which is 100-fold more abundant than mannose in human plasma14, is the biggest source of mannose within the cells15 and considering the higher expression levels of MPI in AML samples, it is plausible that MPI inhibition will be detrimental to AML cells survival and its effects not rescued sufficiently by the relatively low levels of mannose in plasma.