For many cancer types (ACC, KICH, KIRC, LGG, LIHC, LUAD, MESO, PAAD, PARD, SARC, and UCEC), patients with TP53mut tumors, tumors with high expression of cell cycle genes, as well as tumors with low expression of direct p53 targets, had poorer prognosis. The gene discussed is TP53; the disease is cancer.