Building on and expanding previous gene expression studies [35, 36], our analysis focused on the following novel aspects: (i) the influence of TP53 mutation types - either of specific variants or variant classes including LOF, GOF, or DN mutations - on gene expression patterns, (ii) separation of common TP53mut-associated expression changes that are shared between many cancer types and specific expression changes observed only in a single or in a few cancer types, and (iii) changes in the immune tumor microenvironment (TME) associated with TP53 mutations. The gene discussed is TP53; the disease is cancer.