Interestingly, all AML recipients display contraction in the proportion of naïve CD4+ and CD8+ cells (CD44−CD62L+), an expansion in CD4+ and CD8+ T effector memory (CD44+ CD62L−) and a decrease in CD4+ and CD8+ T central memory (CD44+ CD62L+) formation when compared to naïve controls (Fig. 3E, Supplementary Fig. 4B–D). Here, CD8A is linked to acute myeloid leukemia.