PDCD1 and acute myeloid leukemia: As PD-L1 interacts with the immune-suppressive receptor PD-1 on T cells, we determined whether blockade of the PD-1/PD-L1 interaction with anti-PD-1 was able to reactivate an anti-leukemic immune response in immunoedited NrasG12D AML (Fig. 4F).