We generated three genetically distinct models of AML; BCR-ABL + NUP98-HOXA9 (BA/NH), MLL-AF9 (MA9) or AML1-ETO + NrasG12D (AE/NrasG12D), representative of common genetic alterations found in patients with AML3 (Fig. 1A). The gene discussed is MLLT3; the disease is acute myeloid leukemia.