Interestingly, the expression of the co-stimulatory molecule CD80 is also IFNγ responsive38 and mutant Ras has recently been shown to drive a cell-intrinsic interferon response via increased expression of transposable elements39 providing a possible mechanism for the unique surface immunophenotype of the immunogenic NrasG12D AML. The gene discussed is CD80; the disease is acute myeloid leukemia.