We generated three genetically distinct models of AML; BCR-ABL + NUP98-HOXA9 (BA/NH), MLL-AF9 (MA9) or AML1-ETO + NrasG12D (AE/NrasG12D), representative of common genetic alterations found in patients with AML3 (Fig. 1A). Here, RUNX1T1 is linked to acute myeloid leukemia.