Consistent with a specific T cell mediated immune response, we demonstrated that NrasG12D AML (Rag2−/−γc−/−) increases T cell proliferation upon co-culture in comparison to non-transformed BM (Rag2−/−γc−/−) whereas MA9 AML did not (Fig. 3C, D). The gene discussed is RAG2; the disease is acute myeloid leukemia.