For instance, Ago2 is involved in the cell cycle in prostate cancer (PCA) [50, 51]; and as a chromosomal passenger complex (CPC), RCC2 plays a non-negligible role in all cell cycle phases [52]; JRK is related to a chromosomal centromeric locus in G(2) [53]. The gene discussed is JRK; the disease is posterior cortical atrophy.