In addition, METTL3 promotes the process of HCC by regulating the m6A levels of USP7 [70]; the increased expression of YTHDF1 enhances the proliferation of HCC cells, which can be achieved by the connection of circMAP2K4 with HSA-Mir-139-5p [71]. This evidence concerns the gene YTHDF1 and hepatocellular carcinoma.