In contrast, the results where obvious signs of AD by T2DM have been reported are based on mutant APP and presenilin in transgenic conditions, therefore, expressing the mutant proteins in cells that would not necessarily express them and at levels that are not regulated by the endogenous promoter (Kalback et al, 2002; Saito et al, 2016). The gene discussed is APP; the disease is type 2 diabetes mellitus.