ABCA1 and Alzheimer disease: In addition, the first GWAS studies conducted on large cohorts of sporadic AD patients supported the notion that processes involving membrane transport were involved in AD pathology, through the identification of AD-associated SNPs in the ATP-binding cassette transporter, members 7 and 1 (ABCA7 and ABCA1, respectively) genomic region (Bellenguez et al, 2022), two proteins involved in the transport of several substrates across cellular membranes (Dean & Annilo, 2005).