MAPT and type 2 diabetes mellitus: Fig 8A and B show that T2DM did not affect the mean level of phosphorylation of tau in Serine 404 in the cerebral cortex of WT animals but did significantly increase it in the cerebral cortex of hAPP NL/F mice. An identical conclusion can be reached by observing the data in Fig 8A and C, which reflect the effect of T2DM on the levels of phosphorylation of tau in the epitope Serine 396: lack of effect in WT mice and significant increase in hAPP NL/F mice.