Therefore, the observed inhibitory effect of T2DM on γ-secretase activity moved us to analyze the effect of this metabolic condition on proteins for synaptic function, focusing on PSD95, which is the core protein of the postsynaptic density and directly anchors neurotransmitter receptors at the synapse (Keith & El-Husseini, 2008). This evidence concerns the gene DLG4 and type 2 diabetes mellitus.