TPP1 and Cerebral atrophy: These findings are directly related to the severity of the disease.16In a case series including 12 patients, 92% had cerebellar atrophy, 67% cerebral atrophy, 83% linear hyperintensity of central white, 50% thinning of the corpus callosum, and 8% had thalamic hypointensity.27A Brazilian case series with 5 patients showed cerebral and cerebellar atrophy in 80% of patients.24The most common neuroimaging findings in patients with atypical CLN2 are cerebral and cerebellar atrophy and white matter abnormalities (consensus; LE: 4), presented in 87% of patients.13