Karshovska et al. (66) reported that a tamoxifen-induced endothelial cell-specific Enpp2 knockout decreased the following: atherosclerosis plaque area, macrophages in lesions, monocyte adhesion, and endothelial expression of CXCL1 in male and female Apoe−/− mice. The gene discussed is CXCL1; the disease is atherosclerosis.