Some of the EV proteins—such as growth differentiation factor 15 (GDF15) in the transforming growth factor–β superfamily and eukaryotic translation initiation factor 3 subunit G (EIF3G), eukaryotic translation elongation factor 1 delta (EEF1D), eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX), and eukaryotic translation initiation factor 3 subunit F (EIF3F) in the EIF family—are identified as potential colon cancer biomarkers. Here, EEF1D is linked to malignant colon neoplasm.