TEAD1 knockout mice showed DCM and embryonic lethality (28), and tamoxifen-inducible adult CM-specific Tead1 ablation in mice led to lethal acute-onset DCM (29), supporting our conclusion that transcriptional dysfunction of TEAD1 in LMNA p.Q353R mice causes DCM. Here, LMNA is linked to familial dilated cardiomyopathy.