A recent report from the Alzheimer’s Disease Neuroimaging Initiative showed cross-sectional associations of elevated ASL/ALT ratio with a diagnosis of Alzheimer’s disease, and including patients with or without cognitive disorders, with poorer cognitive function test scores and positron emission tomography and cerebrospinal fluid biomarkers of amyloid, tau and neurodegeneration [52]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.