A recent report from the Alzheimer’s Disease Neuroimaging Initiative showed cross-sectional associations of elevated ASL/ALT ratio with a diagnosis of Alzheimer’s disease, and including patients with or without cognitive disorders, with poorer cognitive function test scores and positron emission tomography and cerebrospinal fluid biomarkers of amyloid, tau and neurodegeneration [52]. The gene discussed is MAPT; the disease is Cognitive impairment.