Compared with the control cells (Ctl), SOX2-OE significantly upregulated UL123 transcription at 4 h post-infection (hpi), UL44 at 12 hpi, and UL99 at 24 hpi (S2 Fig), and the corresponding viral protein levels in glioma cell lines and primary GSCs (#286 and #352) (Fig 1). Here, SOX2 is linked to central nervous system cancer.