Previous studies proposed several mechanisms including: 1) HCMV IE1 induction of damage DNA [37] and promotion of the stemness properties of GBM cells [38]; 2) HCMV US28 acceleration of GBM growth by facilitating development of an invasive, angiogenic phenotype [39]; and, 3) HCMV encoded viral IL-10 induction of relative immunosuppression in the tumor microenvironment (TME) facilitating gliomagenesis [40]. This evidence concerns the gene IL10 and neoplasm.