CENPE and neoplasm: Additional studies from the Weaver group using mice models and MEF cells further verified that the induction of low levels of chromosomal missegregation promote tumorigenesis (CENP-E + / −  alone), whereas higher rates of chromosome missegregation (CENP-E + / − ; Mad2 + / − double heterozygous mice) have the opposite effect and are tumor suppressive (Funk et al. 2016; Silk et al. 2013).