In this regard, several seminal studies have unveiled that CIN-high tumors instigate chronic inflammatory responses via the cGAS-STING pathway and non-canonical NF-kB activation that mediate invasion and metastasis (Bakhoum and Cantley 2018; Bakhoum et al. 2018). Here, STING1 is linked to cervical squamous intraepithelial neoplasia.