Importantly, tumor-associated Pcdh10 methylation status exhibit diagnostic and prognostic value for multiple human cancers, such as colorectal cancer, prostate cancer, cervial cancer, breast cancer, etc. (Lin et al. 2011; Jao et al. 2014; Deng et al. 2016; Liu et al. 2018b). This evidence concerns the gene PCDH10 and Familial prostate cancer.