PCDH10 and medical procedure: Several studies have reported that aberrant CpG methylation of the Pcdh10 promoter is observed in 43–85% of colorectal cancer tissues, indicating that downregulated Pcdh10 caused by methylation is a common feature of colorectal carcinogenesis (Yu et al. 2010; Silva et al. 2013; Zhong et al. 2013).