IL4 and neoplasm: Likewise, spheroidal MSCs transfected with a potent anti-inflammatory cytokine IL-4 enhanced anti-inflammatory effects and chondroprotective in OA rats model and in an OA chondrocyte model [152], whereas MSCs engineered anti-tumor activity cytokine, IL-12, prolong the tumor-bearing mouse survival and decrease tumor growth after intravenous injection, including carcinoma, renal cell carcinoma (RCC), breast tumor, and melanoma [73, 153].