Similarly, in Fus∆NLS/+ mice, a conditional knock-in mice expressing an ALS-like truncated FUS protein [60, 63], MCH neuronal positive cells were similar to wild-type littermate mice at 3 months of age yet decreased at 10 months of age, an age at which cognitive and motor symptoms are present [61, 62] (Fig. 1c, d). The gene discussed is PMCH; the disease is amyotrophic lateral sclerosis.