LncRNA GAS5 inhibits miR-579-3p to activate the SIRT1/PGC-1α/Nrf2 signaling pathway and reduces cell scorching in sepsis-related kidney injury.[54] LncRNA MALAT1 promotes HG-induced renal tubular epithelial cell pyroptosis by targeting NLRP3 through sponge miR-30c.[55] LncRNA NEAT2 regulates HG-induced tubular cell pyroptosis in DN through miR-206.[56] All of these are involved in the regulation of pyroptosis occurrence in kidney disease (Fig. 2). Here, MALAT1 is linked to kidney disorder.