Downregulating of IRE1α and upregulating miR-200a to suppress TXNIP reduces the occurrence of pyroptosis.[39] Besides, miR-34c, as a target gene of lcnRNA NEAT1, can also mediate the effect of NEAT1 on DN cell pyroptosis by regulating NLRP3 expression as well as caspase-1 and IL-1β expression.[40] Moreover, miR-23a-3p targeting NEK7 alleviates NLRP3-induced pyroptosis and liver and kidney injury in type 2 diabetic rats.[41] MiR-200c is also involved in atorvastatin to protect podocytes from high-glucose-induced pyroptosis and oxidative stress, providing a potential target for DN. The gene discussed is ERN1; the disease is liver dysplastic nodule.