MiR-20a may cause AKI in septic rats through activation of autophagy.[24] In contrast, miR-214 can ameliorate sepsis-induced AKI through PTEN/AKT/mTOR-regulated autophagy.[25] Ischemia/reperfusion injury (IRI) plays major role in renal transplantation and is one of the major causes of AKI or even renal graft failure. Here, PTEN is linked to acute kidney injury.