AKI is characterized by a sustained loss of renal function.[62] Heme oxygenase-1 gradually decreased with increasing reoxygenation time, while miR-3587 expression was steadily upregulated, and administration of miR-3587 inhibitor enhanced HO-1 expression and inhibited HR-induced ferroptosis in NRK-52E cells.[63] MiRNAs can also play their functional roles by cooperating with other non-coding RNAs. This evidence concerns the gene HMOX1 and acute kidney injury.