MTOR and acute kidney injury: MiR-20a may cause AKI in septic rats through activation of autophagy.[24] In contrast, miR-214 can ameliorate sepsis-induced AKI through PTEN/AKT/mTOR-regulated autophagy.[25] Ischemia/reperfusion injury (IRI) plays major role in renal transplantation and is one of the major causes of AKI or even renal graft failure.