Potential targets of 99 miRNAs suggested that inflammatory and immune processes, identified necroptosis specifications, and supported the renal tubular cell phenotype changes in the pathogenesis of DN.[71] RIP1/RIP3 pathway is involved in the regulation of renal IRI induced cell necrosis.[72] Recently, miR-124 was found to attenuate renal IRI by negatively regulating PARP1 through inhibiting the TNFα/RIP1/RIP3 pathway and rescued the miR-124.[73] MiR-26a-5p alleviated apoptosis by inhibiting the expression of RIP1, RIP3, and MLKL in necrotizing apoptosis.[74]. This evidence concerns the gene RIPK3 and liver dysplastic nodule.