AKT1 and osteoarthritis: “Inhibition of the PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis,” published in 2017 by Xue et al, was the most frequently cited article in the last decade.[17] The authors indicated that inflammation could inhibit the proliferation and cell cycle of chondrocytes and reduce the autophagy rate.