ACE and cancer: AKI occurs more with advanced cancer stages, CKD, and diabetes.[22] The co-prescription of a diuretic and an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker was associated with increased AKI rate in individuals aged 66 years and had systematic antitumor therapy.[22] Another recent Chinese study found that 14% to 20% of cancer patients had AKI.[22]