At the same time, focal segmental glomerulosclerosis and AIN have also been seen with severe HTN.[121] Vemurafenib and dabrafenib, serine/threonine kinase BRAF (BRAF is “v-RAF murine sarcoma viral oncogene homolog B1”) inhibitors, have been associated with dose-related AKI.[122] Although there is little histological information available,[122] it is likely that the suppression of the mitogen-activated protein kinase pathway causes acute tubular necrosis damage. This evidence concerns the gene BRAF and acute kidney injury.