IL6 and acute kidney injury: The well-known causes of AKI include older drugs like interferon and high-dose interleukin (IL)-2.[123] Although the cytokines IL-6 and -13 may also be involved, natural interferon binding to podocyte receptors and modification of normal cellular proliferation may enhance podocyte damage.[123] High-grade proteinuria from focal segmental glomerulosclerosis or minimal change nephropathy is a common clinical symptom of interferon-associated AKI.