As data displayed in Figure 3A, we found that high-expression of YKT6 was positively correlated with poor prognosis of OS in different types of tumors including ACC (P = .0029), BLCA (P = .022), CESE (P = .04), Head and Neck squamous cell carcinoma (HNSC, P = .00034), LGG (P = .00025), LIHC (P = .0013), LUAD (P = .017), MESO (P = .025), and UVM (P = .00094). This evidence concerns the gene YKT6 and head and neck squamous cell carcinoma.