VEGFA and polycystic ovary syndrome: In addition, it affects the quality of follicular mature oocytes, during pregnancy and embryo growth and development, high VEGFA concentration in follicular fluid in patients with PCOS can lead to an increase in immature follicles and a decrease in fertilized eggs.[21–23] EGFR is the most abundant expression in human GC and follicular fluid, has been shown to be an ovulation induction factor.