IL-6 is a group of cytokines secreted by granulosa cells (GC), Studies have shown that IL-6 plays different roles in follicular generation, ovulation and luteal function, and is involved in the local inflammatory immune response of ovary, which is an influential factor of non-ovulation in PCOS patients.[13,20] Studies have shown that VEGFA is expressed in ovarian GC and membrane cells, as well as in follicular fluid. Here, VEGFA is linked to polycystic ovary syndrome.