PNLIP and obesity due to melanocortin 4 receptor deficiency: Besides, they can act on the most diverse proteins, such as tyrosine phosphatase 1B,[17] AMP-activated protein kinase,[18] interleukin 6 and chemokine ligand 2 [19] and pancreatic lipase,[20] that are proteins involved in the metabolism of both diseases, obesity, and DM.