MHC class II chaperone invariant chain (Cd74 or Ii) and MHC class I component beta-2-microglobulin (B2m) are required components of the antigen processing/presentation machinery that are expressed by a subset of oligodendroglia in mouse inflammatory models (Falcão et al., 2018) and human MS brain (Schirmer et al., 2019; Jäkel et al., 2019). This evidence concerns the gene CD74 and myeloid sarcoma.