We chose to target B2m and Cd74 genes for the generation of MHC class I and MHC class II reporter mice, respectively, as both of these transcripts are upregulated in oligodendroglia in response to IFN-γ treatment (Kirby et al., 2019), and both transcripts are present in inflammatory oligodendroglia in mouse inflammatory models (Falcão et al., 2018) and human MS tissue (Schirmer et al., 2019; Jäkel et al., 2019). This evidence concerns the gene CD74 and myeloid sarcoma.