For the most frequently mutated genes, a similar mutation rate was noted between primary colorectal cancer and CRLM (Fig. 1A): APC 69% primary colorectal cancer and 85% CRLM; TP53 54% and 54%; ARID1A 46% and 31% and KRAS 38% and 46%. This evidence concerns the gene TP53 and colorectal cancer.