IFNA1 and colorectal cancer: When pairwise comparison of each group was performed using GSEA and plotted in a clustered heatmap, concordant immune pathways enrichment for KMhigh and KMlow Stromahigh tumors was demonstrated in both primary colorectal cancer and CRLM, including antigen presentation, costimulatory signaling, immune cell adhesion and migration, lymphoid compartment, and IFN signaling (Fig. 2D).