Co-abundance analysis of CD3 and CD66b demonstrated that within primary colorectal cancer IE, CD3 and CD66b were strongly correlated (rho = 0.619, P = 0.006); however, this was not the case in the CRLM (rho = 0.189, P = n.s.; Fig. 3D). Here, CEACAM8 is linked to colorectal cancer.