Although studies have revealed that LRH‐1 regulates hepatocyte metabolism and affects the survival or death of cancer cells by participating in mitochondrial Gln metabolism,15 it remains unknown whether LRH‐1 is involved in podocyte Gln metabolism and its effect on DKD‐induced podocyte injury has still not been fully clarified. The gene discussed is NR5A2; the disease is diabetic kidney disease.