It was reported that in breast cancer AP-1 transcription factor components, i.e., JUN, JUNB, FOS, FOSB, in addition to DUSP1, EGR1, NR4A1, IER2 and BTG2, behave as a conserved co-regulated network 14, most of which are transcriptional factors. The gene discussed is DUSP1; the disease is breast cancer.