In a recent paper, Vos et al.24 described a single case-report reporting a 54 years-old male patient with a diffuse pigmentation of the hard palate, involving also a small part of the soft palatal mucosa; during the differential diagnosis, in addition to the immunoreactions for Melan-A, HMB-45 and p16, the authors used the PRAME immunostaining that was strongly positive: the histological diagnosis was melanoma in situ, further demonstrating the usefulness of PRAME in such lesions. Here, MLANA is linked to in situ carcinoma.