Further bioinformatics analyses identified four important genes (FOS, SERPINE1, AKR1C3, and FGF2) and several active molecules (4', 5, 7-trihydroxyflavone; ethyl protocatechuate; 3, 5-dihydroxy-benzoic acid; curculigosaponin A; and curculigine G) with potential therapeutic roles in the activity of D. indica against HCC. Here, AKR1C3 is linked to hepatocellular carcinoma.