In the connection degree analysis, the top four key genes, FOS, SERPINE1, AKR1C3, and FGF2 (AKR1C3 and FGF2 showed the same connection degree), exhibited strong connections with other genes in the PPI network, suggesting a crucial role in the activity of D. indica against HCC. The gene discussed is AKR1C3; the disease is hepatocellular carcinoma.